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Betty Crocker’s Cheese Sandwich Casserole

This cheese sandwich casserole transforms simple sandwich ingredients into a comforting, golden-brown masterpiece. With a creamy egg custard soaking through buttered bread and melted cheese throughout, it’s perfect for breakfast, brunch, or a cozy dinner.
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Prep Time 15 minutes
Cook Time 30 minutes
Total Time 45 minutes
Servings: 4 servings
Course: Main Course
Cuisine: American
Calories: 485
Ingredients Equipment Method Notes

Ingredients
  

For the Casserole
  • 12 slices white or wheat sandwich bread
  • 2 tablespoons butter softened
  • 2 cups shredded cheddar cheese or Colby-Jack mix divided
  • 3 large eggs
  • 2 cups whole milk
  • 1/2 teaspoon salt
  • 1/4 teaspoon ground black pepper
  • 1/4 teaspoon dry mustard optional, for flavor boost
  • 1 small onion finely chopped, optional

Equipment

  • 9x13-inch baking dish
  • Mixing bowl
  • Oven

Method
 

  1. Preheat your oven to 350°F and lightly grease a 9×13-inch baking dish.
  2. Spread the 2 tablespoons of softened butter over one side of each of the 12 bread slices.
  3. Arrange 6 slices, buttered side down, in your prepared baking dish to form the base of the casserole.
  4. Sprinkle 1 cup of the shredded cheese evenly over the bottom layer. If using, scatter the finely chopped onion over the cheese.
  5. Place the remaining 6 bread slices on top with the buttered side facing up, and sprinkle the remaining 1 cup of cheese over them.
  6. In a separate bowl, whisk together the 3 large eggs, 2 cups of whole milk, 1/2 teaspoon salt, 1/4 teaspoon ground black pepper, and 1/4 teaspoon dry mustard (if using) until well blended.
  7. Pour the custard mixture evenly over the assembled casserole and let it sit for about 10 minutes so the bread can soak up the liquid.
  8. Bake uncovered in the preheated oven for 30–35 minutes until the custard is set and the top turns golden brown.
  9. Remove from the oven and let the casserole cool for a few minutes before serving.

Notes

This casserole is wonderfully versatile and can be easily customized with different cheeses or add-ins like bacon, ham, or vegetables. For an extra indulgent version, substitute half-and-half for part of the milk. Make-ahead tips include assembling the casserole and refrigerating overnight, then baking when ready to serve. It pairs well with a crisp salad or a bowl of tomato soup to balance its rich flavors.